Affordable Access

Vasorelaxant effects of the chronic treatment with melatonin on mesenteric artery and aorta of spontaneously hypertensive rats.

Authors
  • Girouard, H
  • Chulak, C
  • Lejossec, M
  • Lamontagne, D
  • de Champlain, J
Type
Published Article
Journal
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Aug 01, 2001
Volume
19
Issue
8
Pages
1369–1377
Identifiers
PMID: 11518844
Source
Medline
License
Unknown

Abstract

The present study showed that melatonin exerted a bradycardic and an antihypertensive action in SHR. The enhancement by melatonin of the endothelium-dependent vasodilation (Ach and/or A23187) in mesenteric artery and aorta from SHR and WKY rats and the higher increase in MAP following L-NAME treatment in melatonin-treated SHR suggest the contribution of an improved vascular NOS pathway activity in the hypotensive effect of melatonin.

Report this publication

Statistics

Seen <100 times