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Vasopressin-dependent and -independent control of the release of adrenocorticotropin.

Authors
  • Carlson, D E
  • Dornhorst, A
  • Seif, S M
  • Robinson, A G
  • Gann, D S
Type
Published Article
Journal
Endocrinology
Publication Date
Feb 01, 1982
Volume
110
Issue
2
Pages
680–682
Identifiers
PMID: 6276148
Source
Medline
License
Unknown

Abstract

We tested the possibility that vasopressin mediates the responses of adrenocorticotropin (ACTH) to electrical stimulation of various areas of the hypothalamus. Thirty-three cats were anesthetized with chloralose-urethane, immobilized with gallamine, and respired artificially. Plasma ACTH was measured by RIA. Intraventricular administration of antiserum to vasopressin blocked the release of ACTH induced by electrical stimulation of the paraventricular nucleus (PVN), suggesting a role for the vasopressinergic projection from PVN to the external zone of the median eminence. In contrast, the release of ACTH induced by stimulation of areas ventral to PVN was unaffected by the antiserum. Thus, there is at least one corticotropin releasing factor released from nuclei other than PVN that is distinct from vasopressin.

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