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Vasodilating effect of estrogen on the human umbilical artery.

Authors
  • Silva de Sá, M F
  • Meirelles, R S
Type
Published Article
Journal
Gynecologic investigation
Publication Date
Jan 01, 1977
Volume
8
Issue
5-6
Pages
307–313
Identifiers
PMID: 612495
Source
Medline
License
Unknown

Abstract

The effects of estradiol, estrone and estriol on the tonus of the isolated vascular segments of human umbilical artery were studied by a perfusion technique. Estradiol (10 microgram/ml), estrone (10 microgram/ml) or estriol (2 and 10 microgram/ml) produce relaxation of the vascular bed which was reflected in a significant reduction in basal pressure of segments perfused at constant rate. A dose-dependent relationship was demonstrated for estriol. The time dependence and extent of relation were similar for all three natural estrogens.

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