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Vasoactive actions of local anaesthetics on human isolated umbilical veins and arteries.

Authors
  • Monuszko, E
  • Halevy, S
  • Freese, K
  • Liu-Barnett, M
  • Altura, B
Type
Published Article
Journal
British journal of pharmacology
Publication Date
Jun 01, 1989
Volume
97
Issue
2
Pages
319–328
Identifiers
PMID: 2758218
Source
Medline
License
Unknown

Abstract

1. An in vitro study, using helical preparations of human umbilical arteries and veins obtained from healthy women at term pregnancy, was designed to determine: (a) whether three local anaesthetics commonly utilized in obstetric anaesthesia (bupivacaine, 2-chloroprocaine, and lignocaine) can induce contraction or relaxation of resting umbilical vessels; (b) whether these agents can induce contraction or relaxation of umbilical vessels which have been previously induced to contract by a known activator, potassium chloride (KCl); and (c) the relative potency of these agents as compared to KCl. 2. The results indicate that: (a) these local anaesthetics are vasoactive on human umbilical vascular smooth muscle; (b) bupivacaine induces contraction in over 90% of the resting vessels examined, while 2-chloroprocaine consistently causes relaxation and lignocaine causes a small degree of contraction in 40% of vessels examined; (c) bupivacaine causes further contraction (or potentiation) of KCl-contracted muscle in 50% of the vessels studied, while 2-chloroprocaine and lignocaine both induce relaxation of these contracted vessels.

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