Affordable Access

Access to the full text

Vasculogenic mimicry in carcinogenesis and clinical applications

Authors
  • Luo, Qingxi1
  • Wang, Jun1
  • Zhao, Wenyuan1
  • Peng, Zhenzi1
  • Liu, Xianyu1
  • Li, Bin2
  • Zhang, Heng1
  • Shan, Bin3
  • Zhang, Chunfang1
  • Duan, Chaojun1
  • 1 Xiangya Hospital, Central South University, Xiangya Road 87th, Changsha, Hunan, 410008, People’s Republic of China , Changsha (China)
  • 2 Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China , Changsha (China)
  • 3 Washington State University Spokane, Spokane, WA, 99201, USA , Spokane (United States)
Type
Published Article
Journal
Journal of Hematology & Oncology
Publisher
Springer Science and Business Media LLC
Publication Date
Mar 14, 2020
Volume
13
Issue
1
Identifiers
DOI: 10.1186/s13045-020-00858-6
Source
Springer Nature
Keywords
License
Green

Abstract

Distinct from classical tumor angiogenesis, vasculogenic mimicry (VM) provides a blood supply for tumor cells independent of endothelial cells. VM has two distinct types, namely tubular type and patterned matrix type. VM is associated with high tumor grade, tumor progression, invasion, metastasis, and poor prognosis in patients with malignant tumors. Herein, we discuss the recent studies on the role of VM in tumor progression and the diverse mechanisms and signaling pathways that regulate VM in tumors. Furthermore, we also summarize the latest findings of non-coding RNAs, such as lncRNAs and miRNAs in VM formation. In addition, we review application of molecular imaging technologies in detection of VM in malignant tumors. Increasing evidence suggests that VM is significantly associated with poor overall survival in patients with malignant tumors and could be a potential therapeutic target.

Report this publication

Statistics

Seen <100 times