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Vascular endothelial growth factor modulates matrix metalloproteinase-9 expression in asthma.

Authors
  • Lee, Kyung Sun
  • Min, Kyung Hoon
  • Kim, So Ri
  • Park, Seoung Ju
  • Park, Hee Sun
  • Jin, Gong Yong
  • Lee, Yong Chul
Type
Published Article
Journal
American journal of respiratory and critical care medicine
Publication Date
Jul 15, 2006
Volume
174
Issue
2
Pages
161–170
Identifiers
PMID: 16645174
Source
Medline
License
Unknown

Abstract

These results indicate that there is a close relationship between VEGF and MMP-9 expression and that inhibition of VEGF receptor down-regulates the expression of MMP-9. These findings suggest that VEGF signaling regulates MMP-9 expression and plays a critical role in initiation and maintenance of asthma.

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