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Vascular effects of 2-chloroprocaine and sodium metabisulfite on isolated rat aortic rings.

Authors
  • Wills, M H1
  • Johns, R A
  • Stone, D J
  • Moscicki, J C
  • Difazio, C A
  • 1 Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville 22908.
Type
Published Article
Journal
Regional anesthesia
Publication Date
Jan 01, 1989
Volume
14
Issue
6
Pages
271–273
Identifiers
PMID: 2486653
Source
Medline
Language
English
License
Unknown

Abstract

Neurologic deficits have followed the intrathecal injection of 2-chloroprocaine 3% (10(-1) M) with sodium metabisulfite 0.2% (10(-2) M) as a preservative. This study evaluated the effects of varying concentrations of 2-chloroprocaine and sodium metabisulfite, as well as the combination of the two, on the vascular reactivity of isolated rings of rat thoracic aorta. Isolated Sprague-Dawley rat thoracic aortic rings were prepared and connected to force transducers for measurement of isometric tension. The tension produced by log-arithmically increasing concentrations of 2-chloroprocaine, sodium metabisulfite, and their paired combination was measured. Sodium metabisulfite concentrations below 0.2% (10(-2) M) caused a maximum of 40% vasoconstriction compared to control followed by vasodilation with a maximum of 80% at 10(-2) M (the concentration in the former clinical preparation). 2-chloroprocaine alone produced a progressive relaxation at 10(-3) M or higher concentration with a maximum of 130%. The effects of the mixture of sodium metabisulfite and 2-chloroprocaine were identical to the effects produced by 2-chloroprocaine alone. The relaxation effects of 2-chloroprocaine dominate the vasoconstricting effects of sodium metabisulfite when the two drugs are combined.

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