An in vivo study comparing the different methods of caries removal was done in children of age group 6-9 years. Among these patients a total number of 150 carious deciduous teeth were selected. Caries removal was done by hand instruments, airotor and carisolv. The efficacy, time taken and pain experienced by the patient during caries removal was evaluated. The results showed that airotor was the most efficient method (mean value 0.38), while carisolv was the least painful (mean value 0.080) and the most time consuming method (534.8 seconds).