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Various Facets of Pathogenic Lipids in Infectious Diseases: Exploring Virulent Lipid-Host Interactome and Their Druggability.

Authors
  • Dadhich, Ruchika1
  • Kapoor, Shobhna2, 3
  • 1 Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, 400076, India. [email protected] , (India)
  • 2 Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, 400076, India. [email protected] , (India)
  • 3 Wadhwani Research Centre for Bioengineering, Indian Institute of Technology Bombay, Mumbai, 400076, India. [email protected] , (India)
Type
Published Article
Journal
The Journal of Membrane Biology
Publisher
Springer-Verlag
Publication Date
Oct 01, 2020
Volume
253
Issue
5
Pages
399–423
Identifiers
DOI: 10.1007/s00232-020-00135-0
PMID: 32833058
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Lipids form an integral, structural, and functional part of all life forms. They play a significant role in various cellular processes such as membrane fusion, fission, endocytosis, protein trafficking, and protein functions. Interestingly, recent studies have revealed their more impactful and critical involvement in infectious diseases, starting with the manipulation of the host membrane to facilitate pathogenic entry. Thereafter, pathogens recruit specific host lipids for the maintenance of favorable intracellular niche to augment their survival and proliferation. In this review, we showcase the lipid-mediated host pathogen interplay in context of life-threatening viral and bacterial diseases including the recent SARS-CoV-2 infection. We evaluate the emergent lipid-centric approaches adopted by these pathogens, while delineating the alterations in the composition and organization of the cell membrane within the host, as well as the pathogen. Lastly, crucial nexus points in their interaction landscape for therapeutic interventions are identified. Lipids act as critical determinants of bacterial and viral pathogenesis by altering the host cell membrane structure and functions.

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