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Variations in the FTO gene are associated with severe obesity in the Japanese.

  • Hotta, Kikuko1
  • Nakata, Yoshio2
  • Matsuo, Tomoaki2
  • Kamohara, Seika3
  • Kotani, Kazuaki4
  • Komatsu, Ryoya5
  • Itoh, Naoto6
  • Mineo, Ikuo7
  • Wada, Jun8
  • Masuzaki, Hiroaki9
  • Yoneda, Masato10
  • Nakajima, Atsushi10
  • Miyazaki, Shigeru11
  • Tokunaga, Katsuto12
  • Kawamoto, Manabu13
  • Funahashi, Tohru4
  • Hamaguchi, Kazuyuki14
  • Yamada, Kentaro15
  • Hanafusa, Toshiaki16
  • Oikawa, Shinichi17
  • And 7 more
  • 1 Laboratory for Obesity, SNP Research Center, RIKEN, 1-7-22 Suehiro, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan. [email protected] , (Japan)
  • 2 Institute of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan. , (Japan)
  • 3 Medicine and Health Science Institute, Tokyo Medical University, Tokyo, Japan. , (Japan)
  • 4 Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan. , (Japan)
  • 5 Rinku General Medical Center, Osaka, Japan. , (Japan)
  • 6 Toyonaka Municipal Hospital, Osaka, Japan. , (Japan)
  • 7 Otemae Hospital, Osaka, Japan. , (Japan)
  • 8 Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. , (Japan)
  • 9 Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. , (Japan)
  • 10 Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan. , (Japan)
  • 11 Tokyo Postal Services Agency Hospital, Tokyo, Japan. , (Japan)
  • 12 Itami City Hospital, Hyogo, Japan. , (Japan)
  • 13 Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan. , (Japan)
  • 14 Department of Community Health and Gerontological Nursing, Faculty of Medicine, Oita University, Oita, Japan. , (Japan)
  • 15 Division of Endocrinology and Metabolism, Department of Medicine, Kurume University, Fukuoka, Japan. , (Japan)
  • 16 First Department of Internal Medicine, Osaka Medical College, Osaka, Japan. , (Japan)
  • 17 Division of Endocrinology and Metabolism, Department of Medicine, Nippon Medical School, Tokyo, Japan. , (Japan)
  • 18 Department of Anatomy, Biology and Medicine, Faculty of Medicine, Oita University, Oita, Japan. , (Japan)
  • 19 Laboratory for Statistical Analysis, SNP Research Center, RIKEN, Tokyo, Japan. , (Japan)
  • 20 Laboratory for Molecular Medicine, Human Genome Center, The Institute of Medical Science, University of Tokyo, Tokyo, Japan. , (Japan)
Published Article
Journal of human genetics
Publication Date
Jan 01, 2008
DOI: 10.1007/s10038-008-0283-1
PMID: 18379722


Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese. To investigate the relationship between the FTO gene and obesity in the Japanese, we genotyped single nucleotide polymorphisms (SNPs) in the FTO genes from severely obese subjects [n = 927, body mass index (BMI) > or = 30 kg/m2] and normal-weight control subjects (n = 1,527, BMI < 25 kg/m2). A case-control association analysis revealed that 15 SNPs, including rs9939609 and rs1121980, in a linkage disequilibrium (LD) block of approximately 50 kb demonstrated significant associations with obesity; rs1558902 was most significantly associated with obesity. P value in additive mode was 0.0000041, and odds ratio (OR) adjusted for age and gender was 1.41 [95% confidential interval (CI) = 1.22-1.62]. Obesity-associated phenotypes, which include the level of plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure were not associated with the rs1558902 genotype. Thus, the SNPs in the FTO gene were found to be associated with obesity, i.e., severe obesity, in the Japanese.

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