Affordable Access

Variation of sweat sodium and chloride with age in cystic fibrosis and normal populations: further investigations in equivocal cases.

Authors
  • Kirk, J M
  • Keston, M
  • McIntosh, I
  • al Essa, S
Type
Published Article
Journal
Annals of clinical biochemistry
Publication Date
Mar 01, 1992
Volume
29 ( Pt 2)
Pages
145–152
Identifiers
PMID: 1626916
Source
Medline
License
Unknown

Abstract

Patients attending cystic fibrosis clinics had sweat sodium and chloride concentrations measured, were reassessed clinically and had DNA studies performed. Sweat test results were compared with a matched control population. In both populations sweat sodium increased with age up to 12 years, and did not change significantly thereafter. The age-related increase was significantly less in the cystic fibrosis group. Sweat chloride increased with age in normal, but not in cystic fibrosis children. After age 12 years there was no age-related change in the normal group, and a fall with age in the cystic fibrosis group. Sweat chloride provided the best discrimination between normal and cystic fibrosis populations and this was particularly important in older subjects. Combining sweat sodium and chloride results did not improve discrimination. Nine patients were identified with equivocal sweat chloride results. DNA studies showed six of these subjects were heterozygous for the delta F508 mutation in the cystic fibrosis gene. Clinical assessment did not always resolve cases with borderline sweat chloride results.

Report this publication

Statistics

Seen <100 times