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The Variant Gambit: COVID’s Next Move

Authors
  • Plante, Jessica A.1, 2
  • Mitchell, Brooke M.1, 2
  • Plante, Kenneth S.1, 2
  • Debbink, Kari3
  • Weaver, Scott C.1, 2, 4
  • Menachery, Vineet D.1, 2, 4
  • 1 Department of Microbiology and Immunology,
  • 2 World Reference Center for Emerging Viruses and Arboviruses
  • 3 Department of Natural Sciences, Bowie State University, Bowie, MD
  • 4 Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA
Type
Published Article
Journal
Cell Host & Microbe
Publisher
Published by Elsevier Inc.
Publication Date
Mar 01, 2021
Identifiers
DOI: 10.1016/j.chom.2021.02.020
PMCID: PMC7919536
Source
PubMed Central
Keywords
License
Unknown

Abstract

In this review, Plante et al. examine SARS-CoV-2 variants including B.1.1.7 (UK), B.1.351 (RSA), P.1 (Brazil), and B.1.429 (California). They focus on what factors contribute to variant emergence, mutations in and outside the spike protein, and studies needed to understand the impact of variants on infection, transmission, and vaccine efficacy.

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