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The variant gambit: COVID-19’s next move

Authors
  • Plante, Jessica A.1, 2
  • Mitchell, Brooke M.1, 2
  • Plante, Kenneth S.1, 2
  • Debbink, Kari3
  • Weaver, Scott C.1, 2, 4
  • Menachery, Vineet D.1, 2, 4
  • 1 Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA
  • 2 World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA
  • 3 Department of Natural Sciences, Bowie State University, Bowie, MD, USA
  • 4 Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA
Type
Published Article
Journal
Cell Host & Microbe
Publisher
Published by Elsevier Inc.
Publication Date
Mar 01, 2021
Volume
29
Issue
4
Pages
508–515
Identifiers
DOI: 10.1016/j.chom.2021.02.020
PMID: 33789086
PMCID: PMC7919536
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Unknown

Abstract

More than a year after its emergence, COVID-19, the disease caused by SARS-CoV-2, continues to plague the world and dominate our daily lives. Even with the development of effective vaccines, this coronavirus pandemic continues to cause a fervor with the identification of major new variants hailing from the United Kingdom, South Africa, Brazil, and California. Coupled with worries over a distinct mink strain that has caused human infections and potential for further mutations, SARS-CoV-2 variants bring concerns for increased spread and escape from both vaccine and natural infection immunity. Here, we outline factors driving SARS-CoV-2 variant evolution, explore the potential impact of specific mutations, examine the risk of further mutations, and consider the experimental studies needed to understand the threat these variants pose. In this review, Plante et al. examine SARS-CoV-2 variants including B.1.1.7 (UK), B.1.351 (RSA), P.1 (Brazil), and B.1.429 (California). They focus on what factors contribute to variant emergence, mutations in and outside the spike protein, and studies needed to understand the impact of variants on infection, transmission, and vaccine efficacy.

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