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On the variability of manual spike sorting.

Authors
  • Wood, Frank
  • Black, Michael J
  • Vargas-Irwin, Carlos
  • Fellows, Matthew
  • Donoghue, John P
Type
Published Article
Journal
IEEE transactions on bio-medical engineering
Publication Date
Jun 01, 2004
Volume
51
Issue
6
Pages
912–918
Identifiers
PMID: 15188858
Source
Medline
License
Unknown

Abstract

The analysis of action potentials, or "spikes," is central to systems neuroscience research. Spikes are typically identified from raw waveforms manually for off-line analysis or automatically by human-configured algorithms for on-line applications. The variability of manual spike "sorting" is studied and its implications for neural prostheses discussed. Waveforms were recorded using a micro-electrode array and were used to construct a statistically similar synthetic dataset. Results showed wide variability in the number of neurons and spikes detected in real data. Additionally, average error rates of 23% false positive and 30% false negative were found for synthetic data.

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