Variability in β-catenin pulse dynamics in a stochastic cell fate decision in C. elegans
- Authors
- Type
- Published Article
- Journal
- Developmental Biology
- Publisher
- Elsevier
- Publication Date
- May 15, 2020
- Volume
- 461
- Issue
- 2
- Pages
- 110–123
- Identifiers
- DOI: 10.1016/j.ydbio.2020.02.004
- PMID: 32032579
- PMCID: PMC7203549
- Source
- PubMed Central
- Keywords
- Disciplines
- License
- Unknown
Abstract
• The fate of the C. elegans P3.p cell is stochastic. • β-catenin (BAR-1) accumulated in P3.p at the time of the cell fate decision. • There is variability in dynamics of Hox and β-catenin levels during the decision. • BAR-1 accumulated with variable pulse slope and time of pulse onset. • Pulse dynamics bias cell fate at the time of the cell fate decision.
