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Vancomycin-loaded chitosan aerogel particles for chronic wound applications.

Authors
  • López-Iglesias, Clara1
  • Barros, Joana2
  • Ardao, Inés3
  • Monteiro, Fernando J2
  • Alvarez-Lorenzo, Carmen1
  • Gómez-Amoza, José L1
  • García-González, Carlos A4
  • 1 Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, R+D Pharma Group (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain. , (Spain)
  • 2 FEUP-Faculdade de Engenharia, Universidade do Porto, I3S-Instituto de Investigação e Inovação em Saúde, and INEB-Instituto de Engenharia Biomédica, 4200-135 Porto, Portugal. , (Portugal)
  • 3 BioFarma Research group, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), Universidade de Santiago de Compostela, E-15782, Santiago de Compostela, Spain. , (Spain)
  • 4 Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, R+D Pharma Group (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain. Electronic address: [email protected] , (Spain)
Type
Published Article
Journal
Carbohydrate polymers
Publication Date
Jan 15, 2019
Volume
204
Pages
223–231
Identifiers
DOI: 10.1016/j.carbpol.2018.10.012
PMID: 30366534
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Chronic wounds are a prevailing cause of decreased quality of life, being microbial burden a factor hindering the normal wound healing process. Aerogels are nanostructured materials with large surface area (>250 m2/g) and high porosity (>96%). In this work, vancomycin-loaded chitosan aerogel beads were tested as a potential formulation to treat and prevent infections at the wound site. Processing of chitosan in the form of aerogels endowed this polysaccharide with enhanced water sorption capacity and air permeability. The morphological and textural properties of the particles were studied by image and N2 adsorption-desorption analysis and scanning electron microscopy. Vancomycin content and release profiles from aerogel carriers showed a fast drug release that permitted to efficiently achieve local therapeutic levels. Cell studies with fibroblasts and antimicrobial tests against S. aureus showed that the vancomycin-loaded aerogel particles were cytocompatible and effective in preventing high bacterial loads at the wound site. Copyright © 2018 Elsevier Ltd. All rights reserved.

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