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Vancomycin versus linezolid in the treatment of methicillin-resistant Staphylococcus aureus meningitis in an experimental rabbit model.

Authors
  • Calik, Sebnem
  • Turhan, Tuncer
  • Yurtseven, Taskin
  • Sipahi, Oguz Resat
  • Buke, Cagri
Type
Published Article
Journal
Medical Science Monitor
Publisher
"International Scientific Information, Inc."
Publication Date
Nov 01, 2012
Volume
18
Issue
11
Identifiers
PMID: 23111752
Source
Medline
License
Unknown

Abstract

Our results suggest that linezolid is not statistically inferior to vancomycin in the treatment of MRSA meningitis in an experimental rabbit model in 20 mg/kg q12 h dosage; however, it is inferior in 10 mg/kg q12 h dosage. Additional data should gathered to confirm these findings in advance of clinical trials to assess efficacy in humans.

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