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Vancomycin versus linezolid in the treatment of methicillin-resistant Staphylococcus aureus meningitis in an experimental rabbit model.

Authors
Type
Published Article
Journal
Medical Science Monitor
1643-3750
Publisher
International Scientific Literature
Publication Date
Volume
18
Issue
11
Identifiers
PMID: 23111752
Source
Medline

Abstract

Our results suggest that linezolid is not statistically inferior to vancomycin in the treatment of MRSA meningitis in an experimental rabbit model in 20 mg/kg q12 h dosage; however, it is inferior in 10 mg/kg q12 h dosage. Additional data should gathered to confirm these findings in advance of clinical trials to assess efficacy in humans.

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