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The value of the serum neurofilament protein heavy chain as a biomarker for peri-operative brain injury after carotid endarterectomy.

Authors
  • Sellner, Johann
  • Petzold, Axel
  • Sadikovic, Suwad
  • Esposito, Lorena
  • Weber, Martin S
  • Heider, Peter
  • Eckstein, Hans-Henning
  • Hemmer, Bernhard
  • Poppert, Holger
Type
Published Article
Journal
Neurochemical Research
Publisher
Springer-Verlag
Publication Date
Nov 01, 2009
Volume
34
Issue
11
Pages
1969–1974
Identifiers
DOI: 10.1007/s11064-009-9976-x
PMID: 19430903
Source
Medline
License
Unknown

Abstract

This prospective study examined the value of serum neurofilament protein levels for detecting peri-operative brain damage following carotid endarterectomy. An ELISA was used for quantification of neurofilament protein heavy chain (NfH(SMI35)) levels from patients undergoing endarterectomy for symptomatic (n = 17) and asymptomatic high-grade internal carotid artery stenosis (n = 30). All patients underwent diffusion-weighted brain imaging before and after the procedure. NfH(SMI35) levels were significantly higher in patients with a symptomatic carotid artery stenosis (0.131 ng/ml) if compared to asymptomatic patients (0.055 ng/ml, P = 0.01). However, serum NfH(SMI35) levels were not related to signs of brain ischemia on routine brain imaging techniques. Our pilot data suggests that raised NfH(SMI35) serum levels in patients with symptomatic carotid artery disease may be a sensitive biomarker for diffuse ischemic damage to the CNS. We conclude that NfH(SMI35) failed to qualify as a biomarker for peri-operative brain injury in CEA and factors that may have compromised the validation of this biomarker are discussed and need to be taken into account for the design of further studies.

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