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Value of minimum intensity projections for chest CT in COVID-19 patients.

Authors
  • Booz, Christian1
  • Vogl, Thomas J2
  • Joseph Schoepf, U3
  • Caruso, Damiano4
  • Inserra, Maria Cristina5
  • Yel, Ibrahim1
  • Martin, Simon S6
  • Bucher, Andreas M7
  • Lenga, Lukas1
  • Caudo, Danilo8
  • Schreckenbach, Teresa9
  • Schoell, Niklas10
  • Huegel, Christian10
  • Stratmann, Jan11
  • Vasa-Nicotera, Mariuca12
  • Rachovitsky-Duarte, Daniel E13
  • Laghi, Andrea14
  • De Santis, Domenico4
  • Mazziotti, Silvio15
  • D'Angelo, Tommaso16
  • And 1 more
  • 1 Division of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt am Main, Germany. , (Germany)
  • 2 Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt am Main, Germany. , (Germany)
  • 3 Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA.
  • 4 Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA; Department of Radiological Sciences, Oncology and Pathology, Sapienzia University of Rome, Rome, Italy. , (Italy)
  • 5 Department of Radiology, University Hospital Vittorio Emanuele Catania, Catania, Italy. , (Italy)
  • 6 Division of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt am Main, Germany; Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA. , (Germany)
  • 7 Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt am Main, Germany; Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA. , (Germany)
  • 8 Division of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt am Main, Germany; Department of Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy. , (Germany)
  • 9 Department of General and Visceral Surgery, University Hospital Frankfurt, Frankfurt am Main, Germany. , (Germany)
  • 10 Department of Pneumonology, University Hospital Frankfurt, Frankfurt am Main, Germany. , (Germany)
  • 11 Department of Hematology and Oncology, University Hospital Frankfurt, Frankfurt am Main, Germany. , (Germany)
  • 12 Department of Cardiology, University Hospital Frankfurt, Frankfurt am Main, Germany. , (Germany)
  • 13 Oxford Internet Institute, University of Oxford, Oxford, England, United Kingdom. , (United Kingdom)
  • 14 Department of Radiological Sciences, Oncology and Pathology, Sapienzia University of Rome, Rome, Italy. , (Italy)
  • 15 Department of Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy. , (Italy)
  • 16 Department of Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy; Department of Radiology, University Hospital Vittorio Emanuele Catania, Catania, Italy. , (Italy)
  • 17 Division of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt am Main, Germany; Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA. Electronic address: [email protected] , (Germany)
Type
Published Article
Journal
European journal of radiology
Publication Date
Dec 14, 2020
Volume
135
Pages
109478–109478
Identifiers
DOI: 10.1016/j.ejrad.2020.109478
PMID: 33360269
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To investigate whether minimum intensity projection (MinIP) reconstructions enable more accurate depiction of pulmonary ground-glass opacity (GGO) compared to standard transverse sections and multiplanar reformat (MPR) series in patients with suspected coronavirus disease 2019 (COVID-19). In this multinational study, chest CT scans of 185 patients were retrospectively analyzed. Diagnostic accuracy, diagnostic confidence, image quality regarding the assessment of GGO, as well as subjective time-efficiency of MinIP and standard MPR series were analyzed based on the assessment of six radiologists. In addition, the suitability for COVID-19 evaluation, image quality regarding GGO and subjective time-efficiency in clinical routine was assessed by five clinicians. The reference standard revealed a total of 149 CT scans with pulmonary GGO. MinIP reconstructions yielded significantly higher sensitivity (99.9 % vs 95.6 %), specificity (95.8 % vs 86.1 %) and accuracy (99.1 % vs 93.8 %) for assessing of GGO compared with standard MPR series. MinIP reconstructions achieved significantly higher ratings by radiologists concerning diagnostic confidence (medians, 5.00 vs 4.00), image quality (medians, 4.00 vs 4.00), contrast between GGO and unaffected lung parenchyma (medians, 5.00 vs 4.00) as well as subjective time-efficiency (medians, 5.00 vs 4.00) compared with MPR-series (all P < .001). Clinicians preferred MinIP reconstructions for COVID-19 assessment (medians, 5.00 vs 3.00), image quality regarding GGO (medians, 5.00 vs 3.00) and subjective time-efficiency in clinical routine (medians, 5.00 vs 3.00). MinIP reconstructions improve the assessment of COVID-19 in chest CT compared to standard images and may be suitable for routine application. Copyright © 2020 Elsevier B.V. All rights reserved.

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