Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats.

Johanna L Hannan; Omer Kutlu; Bernard L Stopak; Xiaopu Liu; Fabio Castiglione; Petter Hedlund; Arthur L Burnett; Trinity J Bivalacqua

doi:10.1111/jsm.12522

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Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats.

Authors

Hannan, Johanna L
Kutlu, Omer
Stopak, Bernard L
Liu, Xiaopu
Castiglione, Fabio
Hedlund, Petter
Burnett, Arthur L
Bivalacqua, Trinity J

Type

Published Article

Journal

Journal of Sexual Medicine

Publisher

Elsevier

Publication Date

Jun 01, 2014

Volume

11

Issue

6

Pages

1442–1451

Identifiers

DOI: 10.1111/jsm.12522

PMID: 24636283

Source

Medline

Keywords

License

Unknown

Abstract

HDAC-induced pathological signaling in response to BCNI contributes to penile vascular dysfunction. Pharmacological inhibition of HDAC prevents penile fibrosis, normalizes fibronectin expression, and preserves erectile function. The HDAC pathway may represent a suitable target in preventing the progression of ED occurring post-radical prostatectomy.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 07/05/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/24636283

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