Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats.
- Authors
- Type
- Published Article
- Journal
- Journal of Sexual Medicine
- Publisher
- Elsevier
- Publication Date
- Jun 01, 2014
- Volume
- 11
- Issue
- 6
- Pages
- 1442–1451
- Identifiers
- DOI: 10.1111/jsm.12522
- PMID: 24636283
- Source
- Medline
- Keywords
- License
- Unknown
Abstract
HDAC-induced pathological signaling in response to BCNI contributes to penile vascular dysfunction. Pharmacological inhibition of HDAC prevents penile fibrosis, normalizes fibronectin expression, and preserves erectile function. The HDAC pathway may represent a suitable target in preventing the progression of ED occurring post-radical prostatectomy.