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Valproic acid prevents penile fibrosis and erectile dysfunction in cavernous nerve-injured rats.

Authors
  • Hannan, Johanna L
  • Kutlu, Omer
  • Stopak, Bernard L
  • Liu, Xiaopu
  • Castiglione, Fabio
  • Hedlund, Petter
  • Burnett, Arthur L
  • Bivalacqua, Trinity J
Type
Published Article
Journal
Journal of Sexual Medicine
Publisher
Elsevier
Publication Date
Jun 01, 2014
Volume
11
Issue
6
Pages
1442–1451
Identifiers
DOI: 10.1111/jsm.12522
PMID: 24636283
Source
Medline
Keywords
License
Unknown

Abstract

HDAC-induced pathological signaling in response to BCNI contributes to penile vascular dysfunction. Pharmacological inhibition of HDAC prevents penile fibrosis, normalizes fibronectin expression, and preserves erectile function. The HDAC pathway may represent a suitable target in preventing the progression of ED occurring post-radical prostatectomy.

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