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Calcitonin gene-related peptide (CGRP) and migraine current understanding and state of development.

Authors
  • Bigal, Marcelo E
  • Walter, Sarah
  • Rapoport, Alan M
Type
Published Article
Journal
Headache The Journal of Head and Face Pain
Publisher
Wiley (Blackwell Publishing)
Publication Date
Sep 01, 2013
Volume
53
Issue
8
Pages
1230–1244
Identifiers
DOI: 10.1111/head.12179
PMID: 23848260
Source
Medline
Keywords
License
Unknown

Abstract

Calcitonin gene-related peptide (CGRP) is a ubiquitous neuropeptide found at the very centers of the migraine process, both centrally and peripherally. It has been under careful study for approximately 25 years. Several CGRP-receptor antagonists are being evaluated for acute treatment of episodic migraine. Three monoclonal antibodies are being studied for prevention of episodic migraine, and 1 monoclonal antibody is being studied for prevention of chronic migraine. In this review, we discuss the role of CGRP in normal physiology and the consequences of CGRP inhibition for human homeostasis. We then review the current state of development for CGRP-receptor antagonists and CGRP monoclonal antibodies. We close by speculating on the potential clinical role of CGRP antagonism in the acute and preventive treatment of episodic and chronic migraine.

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