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Validation of renal output efficiency as an objective quantitative parameter in the evaluation of upper urinary tract obstruction.

Authors
Type
Published Article
Journal
Journal of Nuclear Medicine
0161-5505
Publisher
Society of Nuclear Medicine
Publication Date
Volume
34
Issue
5
Pages
845–848
Identifiers
PMID: 8478722
Source
Medline

Abstract

This is a preliminary study of the parameter, renal output efficiency (ROE), for the quantitation of furosemide (frusemide) response in diuresis renography. This is calculated by a technique independent of variations in uptake rate by the kidneys. Eleven healthy volunteers and 34 patients suspected of upper urinary obstruction were subjected to gamma camera studies using 99mTc-MAG3 and a standard protocol. Furosemide was given at 18 min after the study was started. The ROE was calculated in each kidney and the results were correlated with final diagnosis. The range of ROE in healthy individuals varied between 82% and 98% (mean = 91.6%); while obstructed kidneys showed significantly reduced values (p < 0.001) ranging between 30% and 76% (mean = 56%). In the diagnosis of urinary obstruction, the ROE has a sensitivity of 91%, specificity of 94% and accuracy of 94%. ROE complements conventional diuresis renography and provides better diagnostic yield in patients with impaired renal function.

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