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Validation of candidate genes associated with cardiovascular risk factors in psychiatric patients.

Authors
  • Windemuth, Andreas1
  • de Leon, Jose
  • Goethe, John W
  • Schwartz, Harold I
  • Woolley, Stephen
  • Susce, Margaret
  • Kocherla, Mohan
  • Bogaard, Kali
  • Holford, Theodore R
  • Seip, Richard L
  • Ruaño, Gualberto
  • 1 Genomas, Inc. and Genetics Research Center, Hartford Hospital, Hartford, CT 06106, USA.
Type
Published Article
Journal
Progress in neuro-psychopharmacology & biological psychiatry
Publication Date
Mar 30, 2012
Volume
36
Issue
2
Pages
213–219
Identifiers
DOI: 10.1016/j.pnpbp.2011.08.001
PMID: 21851846
Source
Medline
License
Unknown

Abstract

The purpose of this study was to identify genetic variants predictive of cardiovascular risk factors in a psychiatric population treated with second generation antipsychotics (SGA). 924 patients undergoing treatment for severe mental illness at four US hospitals were genotyped at 1.2 million single nucleotide polymorphisms. Patients were assessed for fasting serum lipid (low density lipoprotein cholesterol [LDLc], high density lipoprotein cholesterol [HDLc], and triglycerides) and obesity phenotypes (body mass index, BMI). Thirteen candidate genes from previous studies of the same phenotypes in non-psychiatric populations were tested for association. We confirmed 8 of the 13 candidate genes at the 95% confidence level. An increased genetic effect size was observed for triglycerides in the psychiatric population compared to that in the cardiovascular population.

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