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Validation of a New Transcutaneous tcPO2/tcPCO2 Sensor with an Optical Oxygen Measurement in Preterm Neonates

Authors
  • van Weteringen, Willem
  • van Essen, Tanja
  • Gangaram-Panday, Norani H.
  • Goos, Tom G.
  • de Jonge, Rogier C.J.
  • Reiss, Irwin K.M.
Type
Published Article
Journal
Neonatology
Publisher
S. Karger AG
Publication Date
Sep 30, 2020
Volume
117
Issue
5
Pages
628–636
Identifiers
DOI: 10.1159/000510659
PMID: 32998134
Source
Karger
Keywords
License
Green
External links

Abstract

Introduction: Traditional transcutaneous oxygen (tcPO<sub>2</sub>) measurements are affected by measurement drift, limiting accuracy and usability. The new potentially drift-free oxygen fluorescence quenching technique has been combined in a single sensor with conventional transcutaneous carbon dioxide (tcPCO<sub>2</sub>) monitoring. This study aimed to validate optical tcPO<sub>2</sub> and conventional tcPCO<sub>2</sub> against arterial blood gas samples in preterm neonates and determine measurement drift. Methods: In this prospective observational study, during regular care, transcutaneous measurements were paired to arterial blood gases from preterm neonates aged 24–31 weeks of gestational age (GA) with an arterial catheter. Samples were included based on stability criteria and stratified for sepsis status. Agreement was assessed using the Bland-Altman analysis. Measurement drift per hour was calculated. Results: Sixty-eight premature neonates were included {median (interquartile range [IQR]) GA of 26 4/7 [25 3/7–27 5/7] weeks}, resulting in 216 stable paired samples. Agreement of stable samples in neonates without sepsis (n = 38) and with suspected sepsis (n = 112) was acceptable for tcPO<sub>2</sub> and good for tcPCO<sub>2</sub>. However, in stable samples of neonates with sepsis (n = 66), tcPO<sub>2</sub> agreement (bias and 95% limits of agreement) was −32.6 (−97.0 to 31.8) mm Hg and tcPCO<sub>2</sub> agreement was 4.2 (−10.5 to 18.9) mm Hg. The median (IQR) absolute drift values were 0.058 (0.0231–0.1013) mm Hg/h for tcPO<sub>2</sub> and 0.30 (0.11–0.64) mm Hg/h for tcPCO<sub>2</sub>. Conclusion: The accuracy of optical tcPO<sub>2</sub> in premature neonates was acceptable without sepsis, while electrochemically measured tcPCO<sub>2</sub> remained accurate under all circumstances. Measurement drift was negligible for tcPO<sub>2</sub> and highly acceptable for tcPCO<sub>2</sub>.

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