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A valid equation for the well-stirred perfusion limited physiologically based pharmacokinetic model that consistently accounts for the blood-tissue drug distribution in the organ and the corresponding valid equation for the steady state volume of distribution.

Authors
Type
Published Article
Journal
Journal of Pharmaceutical Sciences
1520-6017
Publisher
Elsevier
Publication Date
Volume
99
Issue
1
Pages
475–485
Identifiers
DOI: 10.1002/jps.21798
PMID: 19492340
Source
Medline

Abstract

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