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Vaccines for COVID-19: A Review of Feasibility and Effectiveness

Authors
  • Mehraeen, Esmaeil
  • Dadras, Omid
  • Afsahi, Amir Masoud
  • Karimi, Amirali
  • MohsseniPour, Mehrzad
  • Mirzapour, Pegah
  • Barzegary, Alireza
  • Behnezhad, Farzane
  • Habibi, Pedram
  • Salehi, Mohammad Amin
  • Vahedi, Farzin
  • Heydari, Mohammad
  • Kianzad, Shaghayegh
  • Moradmand-Badie, Banafsheh
  • Javaherian, Mohammad
  • SeyedAlinaghi, SeyedAhmad
  • Sabatier, Jean-Marc
Publication Date
Sep 23, 2021
Identifiers
DOI: 10.2174/1871526521666210923144837
PMID: 34554905
OAI: oai:HAL:hal-03357919v1
Source
HAL
Keywords
Language
English
License
Unknown
External links

Abstract

Introduction: Many potential vaccines for COVID-19 are being studied, and several studies have reported the results of these vaccines. We aimed to review the current evidence of the feasibility and effectiveness of Vaccines for COVID-19. Methods: A search was carried out utilizing the keywords in the online databases, including Scopus,Web of Science, PubMed, Embase, and Cochrane. We included both human and non-human studies because of the vaccine novelty, which could limit our ability to include sufficient human studies. Results: The review of studies showed that several SARS-CoV-2 vaccines are under development; different platforms are being used, including eight vaccines are adenovirus-based vectors, six vaccines are RNA-based formulations, one vaccine is DNA-based formulations, and other vaccines are using other platforms, including lipid nano particles. Conclusion: It is crucial to gather as much clinically relevant evidence as possible regarding the immunogenicity, efficacy, and safety profiles of these vaccines and adhere wisely to CDC protocols and guidelines of vaccine production.

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