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Vaccination status and COVID-19 related mortality: A hospital based cross sectional study.

Authors
  • Muthukrishnan, J1
  • Vardhan, Vasu2
  • Mangalesh, Sridhar3
  • Koley, Mrinalini3
  • Shankar, Subramanian4
  • Yadav, Arun Kumar5
  • Khera, Anurag6
  • 1 Consultant & Head (Medicine) & Endocrinologist, Base Hospital, Delhi Cantt, India. , (India)
  • 2 Commandant, Base Hospital, Delhi Cantt, India. , (India)
  • 3 Intern (Medicine), Base Hospital, Delhi Cantt, India. , (India)
  • 4 Consultant (Medicine & Clinical Immunology), Air Cmde AFMS (P & T), O/o DGAFMS, New Delhi, India. , (India)
  • 5 Associate Professor (Community Medicine), Armed Forces Medical College, Pune, India. , (India)
  • 6 Senior Advisor (Community Medicine), ADH, HQ Delhi Area, Delhi, India. , (India)
Type
Published Article
Journal
Medical Journal Armed Forces India
Publisher
Elsevier
Publication Date
Jul 01, 2021
Volume
77
Identifiers
DOI: 10.1016/j.mjafi.2021.06.034
PMID: 34334894
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Efficacy of vaccines studied in clinical trial settings are likely to be different from their effectiveness in a real-world scenario. Indian Armed Forces launched its vaccine drive against COVID-19 on 16 Jan 2021. This study evaluated the effect of vaccination on mortality amongst hospitalized COVID patients. A cross sectional study was done on all admitted moderate to severe COVID-19 patients at a designated COVID hospital in New Delhi. The primary outcome assessed the association of being fully vaccinated with mortality. Unadjusted odds ratios (OR) (with 95% CI) was performed for each predictor. Logistic regression was used for multivariable analysis and adjusted odds ratios obtained. The 1168 patients included in the study had a male preponderance with a mean age of 54.6 (± 17.51) years. A total of 266 (23%) patients were partially vaccinated with COVISHIELD® and 184 (16%) were fully vaccinated. Overall, 518 (44.3%) patients had comorbidities and 332 (28.4%) died. Among those fully vaccinated, there was 12.5% (23/184) mortality while it was 31.45 % (309/984) among the unvaccinated (OR 0.3, 95% CI 0.2 to 0.5, p<0.0001). In a logistic regression model, complete vaccination status and younger age were found to be associated with survival. Vaccination with two doses of COVISHIELD® was associated with lower odds of mortality among hospitalized patients with moderate to severe COVID. © 2021 Director General, Armed Forces Medical Services. Published by Elsevier, a division of RELX India Pvt. Ltd.

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