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Vaccination against hepatitis B in preschool children with Down's syndrome.

Authors
  • Vajro, P
  • Lettera, P
  • Fontanella, A
  • Sbreglia, C
  • Manzillo, E
  • Sartorio, R
  • Del Giudice, E
Type
Published Article
Journal
Journal of intellectual disability research : JIDR
Publication Date
Feb 01, 1992
Volume
36 ( Pt 1)
Pages
77–81
Identifiers
PMID: 1533557
Source
Medline
License
Unknown

Abstract

Twenty-nine healthy HBsAg- and HBsAb-negative children with Down's syndrome who were living at home (mean age 42 months; 19 M, 10 F) were vaccinated against hepatitis B virus either with recombinant DNA or plasma-derived vaccine. Both groups of children responded well to the vaccination schedules, with HBsAb seroconversion rates close to 100%. Vaccination against hepatitis B in preschool children with Down's syndrome is effective in spite of the existing abnormalities of the immune function.

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