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Uveal melanoma model with metastasis in rabbits: effects of different doses of cyclosporine A.

Authors
  • Blanco, G
  • Saornil, A M
  • Domingo, E
  • Diebold, Y
  • López, R
  • Rábano, G
  • Tutor, C J
Type
Published Article
Journal
Current eye research
Publication Date
Sep 01, 2000
Volume
21
Issue
3
Pages
740–747
Identifiers
PMID: 11120562
Source
Medline
License
Unknown

Abstract

Different doses of CsA affect survival, tumor development and renal toxicity. Metastatic disease is independent of CsA dose and the subsequent CsA blood levels. A blood level of CsA ranging from 500 to 1000 ng/ml and doses of 10 to 15 mg/kg/day may effectively develop this model of uveal melanoma.

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