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Utility of the radioiodine whole-body retention at 48 hours for modifying empiric activity of 131-iodine for the treatment of metastatic well-differentiated thyroid carcinoma.

Authors
  • Van Nostrand, Douglas
  • Atkins, Frank
  • Moreau, Shari
  • Aiken, Martha
  • Kulkarni, Kanchan
  • Wu, Jingshu S
  • Burman, Kenneth D
  • Wartofsky, Leonard
Type
Published Article
Journal
Thyroid
Publisher
Mary Ann Liebert
Publication Date
Oct 01, 2009
Volume
19
Issue
10
Pages
1093–1098
Identifiers
DOI: 10.1089/thy.2008.0339
PMID: 19732012
Source
Medline
License
Unknown

Abstract

We conclude that, with respect to the treatment of metastatic epithelial cell thyroid cancer, the %WBR(48hr) of 131-I helps identify those patients in whom the empiric therapeutic prescribed activity of 131-I may be increased or should be decreased so as not to exceed the MTA and that Sisson et al.'s thresholds published in 2003 are applicable. We favor a biexponential regression model using the %WBR(48hr) and a lower limit threshold as a potentially useful method for determining how much an empiric therapeutic prescribed activity of 131-I can be increased or decreased.

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