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The utility of immunohistochemistry for the identification of hematopoietic and lymphoid cells in normal tissues and interpretation of proliferative and inflammatory lesions of mice and rats.

Authors
  • Rehg, Jerold E
  • Bush, Dorothy
  • Ward, Jerrold M
Type
Published Article
Journal
Toxicologic Pathology
Publisher
SAGE Publications
Publication Date
Jan 01, 2012
Volume
40
Issue
2
Pages
345–374
Identifiers
DOI: 10.1177/0192623311430695
PMID: 22434870
Source
Medline
License
Unknown

Abstract

Expression of antigens in cells and tissues can be readily studied immunohistochemically with the use of antibodies. A panel of antibodies to cell-specific markers can be used to diagnose lesions, including tumors, in the hematopoietic and lymphoid systems. This review discusses the use of readily available antibodies and procedures to identify antigens expressed in normal tissues and in proliferative and inflammatory lesions in formalin-fixed, paraffin-embedded (FFPE) murine specimens.

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