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Utility of flouro-deoxy-glucose positron emission tomography/computed tomography in the diagnostic and staging evaluation of patients with primary CNS lymphoma.

Authors
  • Gupta, Meetakshi1
  • Gupta, Tejpal1
  • Purandare, Nilendu2
  • Rangarajan, Venkatesh2
  • Puranik, Ameya2
  • Moiyadi, Aliasgar3
  • Shetty, Prakash3
  • Epari, Sridhar4
  • Sahay, Ayushi4
  • Mahajan, Abhishek5
  • Janu, Amit5
  • Bagal, Bhausaheb6
  • Menon, Hari6
  • Kannan, Sadhana7
  • Krishnatry, Rahul1
  • Sastri, Goda Jayant1
  • Jalali, Rakesh1
  • 1 Department of Radiation Oncology, TMH/ACTREC, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai 400012, India. , (India)
  • 2 Department of Nuclear Medicine & Molecular Imaging, TMH/ACTREC, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai 400012, India. , (India)
  • 3 Department of Neuro-surgery, TMH/ACTREC, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai 400012, India. , (India)
  • 4 Department of Pathology, TMH/ACTREC, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai 400012, India. , (India)
  • 5 Department of Radio-diagnosis, TMH/ACTREC, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai 400012, India. , (India)
  • 6 Department of Medical Oncology, TMH/ACTREC, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai 400012, India. , (India)
  • 7 Department of Clinical Research Secretariat, TMH/ACTREC, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai 400012, India. , (India)
Type
Published Article
Journal
CNS Oncology
Publisher
Future Medicine
Publication Date
Dec 01, 2019
Volume
8
Issue
4
Identifiers
DOI: 10.2217/cns-2019-0016
PMID: 31779471
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Aim: To prospectively assess the clinical utility of pretreatment flouro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in patients with primary central nervous system (CNS) lymphoma (PCNSL). Materials & methods: Patients with suspected/proven PCNSL underwent baseline whole-body 18F-FDG-PET/CT. Maximum standardized uptake value and tumor/normal tissue ratios were compared between CNS lymphoma and other histological diagnoses. Results: The mean maximum standardized uptake value (27.5 vs 18.2; p = 0.001) and mean tumor/normal tissue ratio (2.34 vs 1.53; p < 0.001) of CNS lymphoma was significantly higher than other histologic diagnoses. Five of 50 (10%) patients with biopsy-proven CNS lymphomas had pathologically increased FDG-uptake at extraneuraxial sites uncovering systemic lymphoma. Conclusion: Pretreatment whole-body 18F-FDG-PET/CT provides valuable complementary information in the diagnostic and staging evaluation of patients with PCNSL to guide therapeutic decision-making.

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