Affordable Access

deepdyve-link
Publisher Website

The utility of blood neuroendocrine gene transcript measurement in the diagnosis of bronchopulmonary neuroendocrine tumours and as a tool to evaluate surgical resection and disease progression.

Authors
  • Filosso, Pier Luigi1
  • Kidd, Mark2
  • Roffinella, Matteo1
  • Lewczuk, Anna3
  • Chung, Kyung-Min2
  • Kolasinska-Cwikla, Agnieszka4
  • Cwikla, Jaroslaw5
  • Lowczak, Anna5
  • Doboszynska, Anna5
  • Malczewska, Anna6
  • Catalano, Maria1
  • Zunino, Valentina1
  • Boita, Monica1
  • Arvat, Emanuela1
  • Cristofori, Riccardo1
  • Guerrera, Francesco1
  • Oliaro, Alberto1
  • Tesselaar, Margot7
  • Buikhuisen, Wieneke7
  • Kos-Kudla, Beata6
  • And 4 more
  • 1 Department of Thoracic Surgery and Department of Oncology, University of Torino, Torino, Italy. , (Italy)
  • 2 Wren Laboratories, Branford, CT, USA.
  • 3 Department of Endocrinology, Medical University of Gdansk, Gdansk, Poland. , (Poland)
  • 4 Department of Oncology, Institute of Oncology, Warsaw, Poland. , (Poland)
  • 5 Department of Radiology, University of Warmia and Mazury, Olsztyn, Poland. , (Poland)
  • 6 Department of Endocrinology, Medical University of Silesia, Katowice, Poland. , (Poland)
  • 7 Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands. , (Netherlands)
  • 8 Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • 9 Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.
Type
Published Article
Journal
European Journal of Cardio-Thoracic Surgery
Publisher
Oxford University Press
Publication Date
Nov 13, 2017
Identifiers
DOI: 10.1093/ejcts/ezx386
PMID: 29145657
Source
Medline
Keywords
License
Unknown

Abstract

Blood NET gene levels accurately identified BPNETs (100%) and differentiated these from controls, benign and malignant lung disease. Progressive disease could be identified and surgical resection verified. Chromogranin A had no clinical utility. Monitoring NET transcript levels in blood will facilitate management by detecting residual tumour and identifying progressive disease.

Report this publication

Statistics

Seen <100 times