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Rapid and dynamic intracellular patterning of cell-internalized magnetic fluorescent nanoparticles.

Authors
  • Tseng, Peter1
  • Di Carlo, Dino
  • Judy, Jack W
  • 1 Department of Electrical Engineering, California Nanosystems Institute, University of California, Los Angeles, Los Angeles, California, USA. [email protected]
Type
Published Article
Journal
Nano Letters
Publisher
American Chemical Society
Publication Date
August 2009
Volume
9
Issue
8
Pages
3053–3059
Identifiers
DOI: 10.1021/nl901535m
PMID: 19572731
Source
Medline
License
Unknown

Abstract

Conjugated magnetic nanoparticles have recently demonstrated potential in activating unique and specific activity within cells. Leveraging microfabrication, we have developed a technique of localizing nanoparticles to specific, subcellular locations by a micropatterned ferromagnetic substrate. Controlled patterns of nanoparticles were assembled and dynamically controlled with submicrometer precision within live cells. We anticipate that the technique will be useful as a compact, simple method of generating localizable, subcellular chemical and mechanical signals, compatible with standard microscopy.

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