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Using the oocyte donation model to identify early trophoblast pregnenolone production.

Authors
  • Licciardi, Frederick
  • Tan, Orkun
  • Oh, Cheongeun
Type
Published Article
Journal
Journal of Assisted Reproduction and Genetics
Publisher
Springer-Verlag
Publication Date
Jun 01, 2013
Volume
30
Issue
5
Pages
699–702
Identifiers
DOI: 10.1007/s10815-013-9986-0
PMID: 23572091
Source
Medline
License
Unknown

Abstract

This is the first report describing that progesterone's precursor, pregnenolone, increases with time in the very early pregnancy. Because no corpus luteum is present in oocyte recipients, the main source of pregnenolone is the early placenta. Measurements of pregnenolone may provide information concerning early trophoblast function and may represent a method of assessing placental competency.

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