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Using murine colitis models to analyze probiotics–host interactions

Authors
  • Martin Rosique, Rebeca
  • Chain, Florian
  • Miquel, Sylvie
  • Motta, Jean-Paul
  • Vergnolle, Nathalie
  • SOKOL, Harry
  • Langella, Philippe
Publication Date
Jan 01, 2017
Source
HAL-UPMC
Keywords
Language
English
License
Unknown
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Abstract

Probiotics are defined as ‘live microorganisms which when administered in adequate amounts confer a health benefit on the host’. So, to consider a microorganism as a probiotic, a demonstrable beneficial effect on the health host should be shown as well as an adequate defined safety status and the capacity to survive transit through the gastrointestinal tract and to storage conditions. In this review, we present an overview of the murine colitis models currently employed to test the beneficial effect of the probiotic strains as well as an overview of the probiotics already tested. Our aim is to highlight both the importance of the adequate selection of the animal model to test the potential probiotic strains and of the value of the knowledge generated by these in vivo tests.

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