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Using induced pluripotent stem cell neuronal models to study neurodegenerative diseases.

Authors
  • Zhang, Xinwen1
  • Hu, Di2
  • Shang, Yutong2
  • Qi, Xin3
  • 1 Center of Implant Dentistry, School of Stomatology, China Medical University, Shenyang 110002, China; Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. , (China)
  • 2 Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
  • 3 Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Center for Mitochondrial Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: [email protected]
Type
Published Article
Journal
Biochimica et biophysica acta. Molecular basis of disease
Publication Date
Apr 01, 2020
Volume
1866
Issue
4
Pages
165431–165431
Identifiers
DOI: 10.1016/j.bbadis.2019.03.004
PMID: 30898538
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Current application of human induced pluripotent stem cells (hiPSCs) technology in patient-specific models of neurodegenerative disorders recapitulate some of key phenotypes of diseases, representing disease-specific cellular modeling and providing a unique platform for therapeutics development. We review recent efforts toward advancing hiPSCs-derived neuronal cell types and highlight their potential use for the development of more complex in vitro models of neurodegenerative diseases by focusing on Alzheimer's disease, Parkinson's disease, Huntington's disease and Amyotrophic lateral sclerosis. We present evidence from previous works on the important phenotypic changes of various neuronal types in these neurological diseases. We also summarize efforts on conducting low- and high-throughput screening experiments with hiPSCs toward developing potential therapeutics for treatment of neurodegenerative diseases. Lastly, we discuss the limitations of hiPSCs culture system in studying neurodegenerative diseases and alternative strategies to overcome these hurdles. Copyright © 2019 Elsevier B.V. All rights reserved.

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