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Usefulness of transabdominal ultrasonography for assessing ulcerative colitis: a prospective, multicenter study

Authors
  • Kinoshita, Kenji1
  • Katsurada, Takehiko1
  • Nishida, Mutsumi2, 3
  • Omotehara, Satomi2, 3
  • Onishi, Reizo1
  • Mabe, Katsuhiro4
  • Onodera, Aki5
  • Sato, Mami5
  • Eto, Kazunori6
  • Suya, Mitsutoshi7
  • Maemoto, Atsuo8
  • Hasegawa, Toru9
  • Yamamoto, Junji10
  • Mitsumori, Daiki11
  • Yoshii, Shinji12
  • Ono, Kota13
  • Sakamoto, Naoya1
  • 1 Hokkaido University Graduate School of Medicine, Department of Gastroenterology and Hepatology, Kita-15, Nishi-7 Kita-ku, Sapporo, 060-8638, Japan , Sapporo (Japan)
  • 2 Hokkaido University Hospital, Division of Laboratory and Transfusion Medicine, Sapporo, Japan , Sapporo (Japan)
  • 3 Hokkaido University Hospital, Diagnostic Center for Sonography, Sapporo, Japan , Sapporo (Japan)
  • 4 National Hospital Organization Hakodate Hospital, Department of Gastroenterology, Hakodate, Japan , Hakodate (Japan)
  • 5 Tomakomai City Hospital, Department of Clinical Laboratory, Tomakomai, Japan , Tomakomai (Japan)
  • 6 Tomakomai City Hospital, Department of Gastroenterology, Tomakomai, Japan , Tomakomai (Japan)
  • 7 Sapporo Higashi Tokushukai Hospital, Department of Clinical Laboratory, Sapporo, Japan , Sapporo (Japan)
  • 8 Sapporo Higashi Tokushukai Hospital, Inflammatory Bowel Disease Center, Sapporo, Japan , Sapporo (Japan)
  • 9 Ohguro Gastroenterological Hospital, Department of Clinical Laboratory, Sapporo, Japan , Sapporo (Japan)
  • 10 Ohguro Gastroenterological Hospital, Sapporo, Japan , Sapporo (Japan)
  • 11 Sapporo Medical Center NTT EC, Department of Clinical Laboratory, Sapporo, Japan , Sapporo (Japan)
  • 12 Sapporo Medical Center NTT EC, Department of Gastroenterology, Sapporo, Japan , Sapporo (Japan)
  • 13 Hokkaido University Hospital, Clinical Research and Medical Innovation Center, Sapporo, Japan , Sapporo (Japan)
Type
Published Article
Journal
Journal of Gastroenterology
Publisher
Springer Japan
Publication Date
Dec 05, 2018
Volume
54
Issue
6
Pages
521–529
Identifiers
DOI: 10.1007/s00535-018-01534-w
Source
Springer Nature
Keywords
License
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Abstract

BackgroundTransabdominal ultrasonography (US) has been reported to be a useful tool for evaluating ulcerative colitis (UC) although with less well-established data than for Crohn’s disease. This prospective multicenter study aimed to establish the usefulness of US compared with colonoscopy (CS) for assessing disease extent and activity of UC.MethodsAltogether, 173 patients with UC were prospectively enrolled, among whom 156 were eligible for this study. All patients underwent US and CS within 2 days at five facilities. We divided the colon into six segments and examined each segment and the rectum using US and CS. US severity was graded 1–4 regarding bowel wall thickness, stratification, and ulceration. CS severity was also graded 1–4 according to Matts’ endoscopic classification. Concordance between US and CS grades for all colonic segments was analyzed using kappa statistics. US and CS findings were also compared with the clinical disease activity index (CAI) and histological grade using Spearman's correlation coefficient.ResultsThere was moderate concordance between US and CS grades in all colonic segments (weighted κ = 0.55, p < 0.001). Concordance was rated moderate for each colonic segment but only slight for the rectum. The US grade was significantly correlated with the CAI score (r = 0.40, p < 0.001) and histological grade (r = 0.35, p < 0.001).ConclusionsThis prospective multicenter study showed moderate concordance between US and CS for assessing the disease activity of UC. Hence, US may be used more generally for evaluating UC in daily clinical practice.

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