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The usefulness of simple X-ray powder diffraction analysis for counterfeit control--the Viagra example.

Authors
Type
Published Article
Journal
Journal of Pharmaceutical and Biomedical Analysis
0731-7085
Publisher
Elsevier
Publication Date
Volume
43
Issue
4
Pages
1514–1518
Identifiers
PMID: 17127026
Source
Medline
License
Unknown

Abstract

Counterfeit and illegally manufactured drugs become a very important problem all over the world, hence, a search for new fast, easy, reliable and not expensive methods of drugs screening is essential. We describe the use of X-ray powder diffraction method for the fast screening of tablets for counterfeit medicines identification. The original Viagra tablets and some counterfeit and/or imitations of Viagra were used as example. We demonstrate the application of diffraction method for discrimination of tablets coatings and for identification of differences in drug composition. The X-ray diffraction method turns out to be very fast and reliable for detecting counterfeits and imitation, and it correctly predicts the presence or absence of active substance and/or particular excipients.

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