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The usefulness of clinical-practice-based laboratory data in facilitating the diagnosis of dengue illness.

Authors
  • Liu, Jien-Wei
  • Lee, Ing-Kit
  • Wang, Lin
  • Chen, Rong-Fu
  • Yang, Kuender D
Type
Published Article
Journal
BioMed Research International
Publisher
Hindawi Limited
Publication Date
Jan 01, 2013
Volume
2013
Pages
198797–198797
Identifiers
DOI: 10.1155/2013/198797
PMID: 24455678
Source
Medline
License
Unknown

Abstract

Alertness to dengue and making a timely diagnosis is extremely important in the treatment of dengue and containment of dengue epidemics. We evaluated the complementary role of clinical-practice-based laboratory data in facilitating suspicion/diagnosis of dengue. One hundred overall dengue (57 dengue fever [DF] and 43 dengue hemorrhagic fever [DHF]) cases and another 100 nondengue cases (78 viral infections other than dengue, 6 bacterial sepsis, and 16 miscellaneous diseases) were analyzed. We separately compared individual laboratory variables (platelet count [PC] , prothrombin time [PT], activated partial thromboplastin time [APTT], alanine aminotransferase [ALT], and aspartate aminotransferase [AST]) and varied combined variables of DF and/or DHF cases with the corresponding ones of nondengue cases. The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) in the diagnosis of DF and/or DHF were measured based on these laboratory variables. While trade-off between sensitivity and specificity, and/or suboptimal PPV/NPV was found at measurements using these variables, prolonged APTT + normal PT + PC < 100 × 10(9) cells/L had a favorable sensitivity, specificity, PPV, and NPV in diagnosis of DF and/or DHF. In conclusion, these data suggested that prolonged APTT + normal PT + PC < 100 × 10(9) cells/L is useful in evaluating the likelihood of DF and/or DHF.

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