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Usefulness of 11C-methionine-PET for predicting the efficacy of carbon ion radiation therapy for head and neck mucosal malignant melanoma.

Authors
  • Hasebe, M1
  • Yoshikawa, K2
  • Nishii, R3
  • Kawaguchi, K4
  • Kamada, T3
  • Hamada, Y4
  • 1 Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine, Tsurumi, Yokohama, Japan; The Hospital of the National Institute of Radiological Sciences, Chiba, Japan. , (Japan)
  • 2 The Hospital of the National Institute of Radiological Sciences, Chiba, Japan; Tokyo Bay Advanced Imaging and Radiation Oncology Clinic, Toyosuna, Chiba, Japan. Electronic address: [email protected] , (Japan)
  • 3 The Hospital of the National Institute of Radiological Sciences, Chiba, Japan. , (Japan)
  • 4 Department of Oral and Maxillofacial Surgery, Tsurumi University School of Dental Medicine, Tsurumi, Yokohama, Japan. , (Japan)
Type
Published Article
Journal
International journal of oral and maxillofacial surgery
Publication Date
Oct 01, 2017
Volume
46
Issue
10
Pages
1220–1228
Identifiers
DOI: 10.1016/j.ijom.2017.04.019
PMID: 28535963
Source
Medline
Keywords
License
Unknown

Abstract

The aim of this study was to determine whether l-methyl-[11C]-methionine (MET) positron emission tomography (PET) allows the prediction of outcomes in patients with head and neck mucosal malignant melanoma treated with carbon ion radiation therapy (CIRT). This was a retrospective cohort study involving 85 patients who underwent a MET-PET or MET-PET/computed tomography (CT) examination before and after CIRT. MET uptake in the tumour was evaluated semi-quantitatively using the tumour-to-normal tissue ratio (TNR). Local recurrence, metastasis, and outcome predictions were studied in terms of TNR before CIRT (TNRpre), TNR after CIRT (TNRpost), and the TNR change ratio. Kaplan-Meier curves revealed significant differences between patients with higher TNRpre values and those with lower TNRpre values in regard to local recurrence, metastasis, and outcome (log-rank test P<0.0001 for all three). There were also significant differences in metastasis rates and outcomes between patients with higher and lower TNRpost values (log-rank test P=0.0105 and P=0.027, respectively). The Cox proportional hazards model revealed TNRpre to be a factor significantly influencing the risk of local recurrence (hazard ratio (HR) 29.0, P<0.001), risk of metastasis (HR 2.67, P=0.024), and the outcome (HR 6.3, P<0.001). MET-PET or MET-PET/CT is useful for predicting the outcomes of patients with head and neck mucosal malignant melanoma treated with CIRT.

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