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The use of wavelet transforms in low-resolution phase extension.

Authors
Type
Published Article
Journal
Acta crystallographica. Section D, Biological crystallography
Publication Date
Volume
56
Issue
Pt 5
Pages
625–633
Identifiers
PMID: 10771432
Source
Medline
License
Unknown

Abstract

A method to extend low-resolution phases has been developed using histogram matching not only of the electron density itself but also of histograms obtained from the different levels of detail provided by the wavelet transform of the electron density. It is shown that the method can extend phases from 10 A to around 6-7 A on a wide range of trial structures differing in size, space group and solvent content. This level of phase extension can improve the electron-density map from little more than a molecular envelope to one in which secondary structure can often be identified.

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