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The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity

Authors
  • Khavinson, V. Kh.1, 2
  • Linkova, N. S.1, 3, 4
  • Chalisova, N. I.1, 2
  • Ivko, O. M.1
  • 1 St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia , St. Petersburg (Russia)
  • 2 Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia , St. Petersburg (Russia)
  • 3 Academy of Postgraduate Education of the Federal State Budgetary Institution, the Federal Science and Clinic Center of the Federal Medical and Biological Agency, Moscow, Russia , Moscow (Russia)
  • 4 Belgorod State University, Belgorod, Russia , Belgorod (Russia)
Type
Published Article
Journal
Biology Bulletin Reviews
Publisher
Pleiades Publishing
Publication Date
Jul 01, 2021
Volume
11
Issue
4
Pages
377–382
Identifiers
DOI: 10.1134/S2079086421040046
Source
Springer Nature
Keywords
Disciplines
  • Article
License
Yellow

Abstract

AbstractThe polypeptide drug thymalin is used for various diseases associated with immune dysfunction, viral and bacterial infections, regeneration normalization, immunodepression, and the depression of hematogenesis after chemical and radiotherapy. The molecular mechanism of the action of thymalin and its components, EW dipeptide (the drug thymogen), the dipeptide KE, and the tripeptide EDP, are analyzed. These short peptides regulate gene expression and the synthesis of heat-shock protein, cytokines, fibrinolysis, gerontogenes, and the differentiation, proliferation, apoptosis of cells. Thymalin and thymogen have practically no side effects and are used for various viral infections. These peptide drugs can likely be effective in the complex therapy for the coronavirus infection COVID-19.

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