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Use of spatiotemporal analysis of laboratory submission data to identify potential outbreaks of new or emerging diseases in cattle in Great Britain

Authors
  • Hyder, Kieran1, 2
  • Vidal-Diez, Alberto1
  • Lawes, Joanna1
  • Sayers, A Robin1
  • Milnes, Ailsa3
  • Hoinville, Linda1
  • Cook, Alasdair JC1
  • 1 Veterinary Laboratories Agency, Centre for Epidemiology & Risk Analysis, New Haw, Addlestone, Surrey, KT15 3NB, UK , Addlestone (United Kingdom)
  • 2 Fisheries and Aquaculture Science, Centre for Environment, Pakefield Road, Lowestoft, Suffolk, NR33 0HT, UK , Lowestoft (United Kingdom)
  • 3 Langford House, Veterinary Laboratories Agency, Langford, Bristol, BS40 5DX, UK , Langford (United Kingdom)
Type
Published Article
Journal
BMC Veterinary Research
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Mar 19, 2011
Volume
7
Issue
1
Identifiers
DOI: 10.1186/1746-6148-7-14
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundNew and emerging diseases of livestock may impact animal welfare, trade and public health. Early detection of outbreaks can reduce the impact of these diseases by triggering control measures that limit the number of cases that occur. The aim of this study was to investigate whether prospective spatiotemporal methods could be used to identify outbreaks of new and emerging diseases in scanning surveillance data. SaTScan was used to identify clusters of unusually high levels of submissions where a diagnosis could not be reached (DNR) using different probability models and baselines. The clusters detected were subjected to a further selection process to reduce the number of false positives and a more detailed epidemiological analysis to ascertain whether they were likely to represent real outbreaks.Results187,925 submissions of clinical material from cattle were made to the Regional Laboratory of the Veterinary Laboratories Agency (VLA) between 2002 and 2007, and the results were stored on the VLA FarmFile database. 16,925 of these were classified as DNRs and included in the analyses. Variation in the number and proportion of DNRs was found between syndromes and regions, so a spatiotemporal analysis for each DNR syndrome was done. Six clusters were identified using the Bernoulli model after applying selection criteria (e.g. size of cluster). The further epidemiological analysis revealed that one of the systemic clusters could plausibly have been due to Johne's disease. The remainder were either due to misclassification or not consistent with a single diagnosis.ConclusionsOur analyses have demonstrated that spatiotemporal methods can be used to detect clusters of new or emerging diseases, identify clusters of known diseases that may not have been diagnosed and identify misclassification in the data, and highlighted the impact of data quality on the ability to detect outbreaks. Spatiotemporal methods should be used alongside current temporal methods for analysis of scanning surveillance data. These statistical analyses should be followed by further investigation of possible outbreaks to determine whether cases have common features suggesting that these are likely to represent real outbreaks, or whether issues with the collection or processing of information have resulted in false positives.

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