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The use of retinoids in ovarian cancer: a review of the literature.

Authors
  • Whitworth, Jenny M
  • Straughn, J Michael Jr
  • Atigadda, Venkatram R
  • Muccio, Donald D
  • Buchsbaum, Donald J
Type
Published Article
Journal
International Journal of Gynecological Cancer
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Feb 01, 2012
Volume
22
Issue
2
Pages
191–198
Identifiers
DOI: 10.1097/IGC.0b013e318236a2ec
PMID: 22146768
Source
Medline
License
Unknown

Abstract

Ovarian cancer is the deadliest of all gynecologic malignancies. The search for novel treatment modalities to augment traditional chemotherapy and improve quality of life is ongoing. Retinoids, a class of compounds composed of vitamin A, its natural derivatives, and synthetic analogs, have been studied extensively in both the prevention and treatment of gynecologic malignancies. In this article, we reviewed preclinical studies and clinical trials conducted using retinoids in ovarian cancer.

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