The use of the three-dimensional (3D) printing technique is gaining popularity due to its ability to produce products with minimum waste. 3D printing can be used to add polymers onto woven fabrics to produce novel structures. This research work concentrated on the study of the fabric properties affecting the adhesion of Polylactic Acid (PLA) polymer onto selected fabrics. Different fabrics made from cotton, polyester and acrylic, were selected and using 3D printing, PLA polymer was printed onto the fabric surface. Regression models were used to study the effect of selected fabric properties on the adhesion of PLA polymer onto the woven fabrics. The results obtained in this research work indicated that fabric areal density, warp count (Tex), weft count (Tex), fabric thickness and fabric handle indicated a positive correlation with adhesion of PLA onto woven fabrics. On the other hand, warp ends/inch and weft picks/inch showed a negative correlation with the adhesion of PLA polymer onto woven fabrics.