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The use of porcine liver (2----3)-alpha-sialyltransferase in the large-scale synthesis of alpha-Neup5Ac-(2----3)-beta-D-Galp-(1----3)-D-GlcpNAc, the epitope of the tumor-associated carbohydrate antigen CA 50.

Authors
  • Lubineau, A1
  • Augé, C
  • François, P
  • 1 Institut de Chimie Moléulaire d'Orsay, U.R.A. C.N.R.S. 462, Université Paris-Sud, France. , (France)
Type
Published Article
Journal
Carbohydrate Research
Publisher
Elsevier
Publication Date
Apr 10, 1992
Volume
228
Issue
1
Pages
137–144
Identifiers
PMID: 1381278
Source
Medline
License
Unknown

Abstract

alpha-Neup5Ac-(2----3)-beta-D-Galp-(1----3)-D-GlcpNAc (2) and, alpha-Neup5Ac-(2----3)-beta-D-Galp-(1----3)-beta-D-GlcpNAcOMBn+ ++ were prepared on a large scale by the action of beta-D-Galp-(1----3)-D-GalpNAc (2----3)-alpha-sialyltransferase (partially purified from porcine liver) on beta-D-Galp-(1----3)-D-GlcpNAc and beta-D-Galp-(1----3)-beta-D-GlcpNAcOMBn, respectively. The trisaccharide 2 is the epitope of the tumor-associated carbohydrate antigen CA 50, highly expressed in human pancreatic adenocarcinoma.

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