This article focuses on best protective materials. The obtaining the solubility parameters of five of the most used polymer materials with forty chemicals covering a broad spectrum of HSP values. The approach considers that for chemical substances that are soluble in a polymer protective material, this material will not be resistant. Inversely, for polymer materials will be resistant. Based on the experimental data, the Hansen the solubility parameters (the center of the sphere) and radii, R, of the polymer spheres for Nit Neoprene, values for the glove materials, the differences with the HSP values (dissimilarity A value following the Hansen approach) for more 1 approach states that for chemicals where the solubility parameter distance (A) of a given chemical to the center of the polymer sphere is higher than the R value, A/R inversely, for A/R the Hansen Sphere with a modified R was developed. An algorithm that compared the predicted values with close to nine hundred experimental data from the literature, allows defining for each material a zone developed that allows the selection of the best glove materials avoiding a dangerous " trial and errors " approach. In any case this software is a substitute of permeation tests to d chemical resistance to a chemical or mixtures of chemicals.