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Use of famciclovir for the treatment of endotheliotrophic herpesvirus infections in Asian elephants (Elephas maximus).

Authors
  • Schmitt, D L
  • Hardy, D A
  • Montali, R J
  • Richman, L K
  • Lindsay, W A
  • Isaza, R
  • West, G
Type
Published Article
Journal
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
Publication Date
Dec 01, 2000
Volume
31
Issue
4
Pages
518–522
Identifiers
PMID: 11428400
Source
Medline
License
Unknown

Abstract

Two juvenile Asian elephants (Elephas maximus) presented with an acute onset of facial edema and lethargy. Examination of the oral cavity of each animal revealed cyanosis of the tip and distal margins of the tongue suggestive of endothelial inclusion body disease (EIBD) of elephants. Whole-blood samples were obtained, and polymerase chain reaction tests confirmed the presence of elephant herpesvirus. The animals were administered famciclovir (Famvir, SmithKline Beecham Pharmaceuticals, Philadelphia, Pennsylvania 19101, USA), a potent human anti-herpesvirus drug, in the course of their disease, and recovery followed a treatment regime of 3-4 wk. These are the first known cases of elephants surviving EIBD.

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