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Use of EDTA samples for prothrombin time measurement in patients receiving oral anticoagulants.

Authors
  • Horsti, J
Type
Published Article
Journal
Haematologica
Publication Date
Aug 01, 2001
Volume
86
Issue
8
Pages
851–855
Identifiers
PMID: 11522542
Source
Medline
License
Unknown

Abstract

A good correlation was observed between INR results with citrate and EDTA samples from patients receiving oral anticoagulants using Owren's PT reagent with the same citrate calibration. Using the regression equation (INR or sec) for analysis of INR results from EDTA samples is clinically acceptable and offers the possibility of using EDTA samples for PT measurement with citrate calibrators. Reagent international sensitivity index (ISI) values for citrate and EDTA samples differ from each other. ISI determination for EDTA samples requires mathematical calculation of EDTA ISI as in the present study or EDTA-based ISI calibrators. The regression equation for INR from citrate and EDTA samples depended on the reagent used, not only on sample dilution or anticoagulant.

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